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More than 6.7 million individuals in the U.S. have Alzheimer’s disease, and that number is growing rapidly. Each day that passes without effective treatments brings tragic consequences for patients and their loved ones. As the debate over coverage for new Alzheimer’s drugs continues, Dr. Jeffrey Cummings of the University of Nevada, Las Vegas, joined us to discuss the challenging path that led to these medicines, the state of the science now, and hope for the future.

More than 6 million Americans are living with Alzheimer's disease, a staggering number that's expected to double within the next 30 years.

Could changing your diet play a role in slowing or even preventing the development of dementia? We're one step closer to finding out, thanks to a new 51³Ô¹ÏºÚÁÏ study that bolsters the long-suspected link between gut health and Alzheimer's disease.

Lighthouse Pharmaceuticals, a clinical-stage pharmaceutical company developing therapeutics to alter the course of dementia and other degenerative diseases, announced completion of a Pre-investigational New Drug meeting with the Food and Drug Administration related to the planned Phase 2b clinical study of LHP588 and the formation of its Clinical Advisory Board (CAB). The CAB includes six members with diverse backgrounds and expertise in dementia, Alzheimer’s disease, inflammation, neurodegenerative disorders, and drug development.

A new drug shows promising results in trials, but questions remain about whether benefits outweigh side effects.

Findings suggest that the amyloid-targeting drug candidate slows cognitive decline in some people, but questions remain over its potential side effects

Results suggest that the amyloid-targeting drug candidate slows cognitive decline in some people, but questions remain over its potential side effects.

In July 2022, a bombshell dropped on the Alzheimer's disease research field. For years, researchers had searched for something that caused the disease’s telltale amyloid plaques — complex tangles of a protein called amyloid-beta (Aβ) frequently found in the brains of patients with neurodegenerative disorders. A series of studies published starting in the mid-2000s reported the discovery of a toxic form of Aβ in the brains of mouse models of Alzheimer's disease called Aβ*56. Researchers hoped that Aβ*56 was the protein that snowballed into those amyloid plaques. But a team of sleuths found that many of the papers describing Aβ*56 were fraudulent and contained an array of faked images and blots. The fraud seemed to call the entire idea of amyloids causing Alzheimer’s disease into question.